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This issue of Viruses is a living memorial dedicated to Professor Stefan Kunz, who passed away too early in life, at 54. During his scientific career, Stefan made major contributions to the field of virology. He made seminal contributions to our understanding of how mammarenaviruses gain access to and are trafficked within their target cells. This issue of Viruses contains a collection of articles by leading researchers in different areas of virus-host cell interactions and who crossed pathways with Stefan. The topics covered in the issue include novel insights on mammeranavirus cell entry, host innate and adaptive immune responses to infection, recent developments on therapeutics against human pathogenic arenaviruses, as well as mammarenavirus ecology and molecular pathogenesis. The collection of articles is also a reflection of Stefan's enthusiasm for exploring new ideas and his very collegial attitude reflected by his many collaborations, including the colleagues who have contributed sections to this memorial issue.
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Fruit- and vegetable-based products (F&Vs) have been conventionally processed using thermal techniques such as pasteurization, scalding, and/and drying, ensuring microbial safety and/or enzyme deactivation. Although thermal treatments are the most cost-effective tools, they could also reduce bioactive compounds, nutrients, and even sensory attributes. Nowadays, non-thermal food-processing technologies such as UV light and high-pressure processing have been proposed to develop food products with extended shelf life and preserved/encouraged bioactive compounds, while preserving the sensory properties. This reprint addresses the existing knowledge gaps of novel thermal and non-thermal techniques in the production of F&Vs and their derivatives. This reprint focuses on the effect of thermal and non-thermal treatments (light stresses, high hydrostatic pressure, pulse electric fields, oscillating magnetic fields, cold plasma, ultrasound, drying, etc.) on shelf-life, key bioactive compound changes (antioxidants, nutraceuticals, flavonoids, and non-flavonoids), enzymatic antioxidant systems, and non-enzymatic antioxidant systems of fruit- and vegetable-based products. Apart from an editorial written by the guest editors, the Special Issue consists of 13 papers that cover a range of subjects: thermal and non-thermal treatments on whole fruits (n = 4); thermal and non-thermal treatments on fruit and vegetable byproducts (n = 3); and, thermal and non-thermal treatments on fruit-based beverages and purées (n = 6).
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Cystic Fibrosis is an inherited disease that starts in utero. It is caused by a defective protein called the CF transmembrane conductance regulator (CFTR) and while the effects are seen throughout the body, changes in the lungs, gastrointestinal tract, pancreas and liver primarily impact nutritional status. Survival and pulmonary function have been linked to nutritional status. Malnutrition and growth failure were historically the hallmark of disease. Patients with pancreatic insufficiency require pancreatic enzyme replacement therapy and fat-soluble vitamin supplements. With improvements in many areas including newborn screening, nutrition supplements, pancreatic enzymes, CFTR modulator drugs, inhaled antibiotics and mucolytics, life expectancy has increased. In this issue, we will review the latest information in children and adults regarding important factors that play a role in optimizing nutrition status, including body composition, the gut microbiome, food security, pancreatic enzyme replacement therapy, growth and bone health, and micronutrient abnormalities. Pediatric and adult providers both need to be aware of the nuances of care as more patients with CF become adults. Optimizing nutritional status, anticipating and preventing the complications of CF will result in best management practice.
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It is currently apparent that extracellular ATP's physiological effect is mediated by its interaction with specific purinergic receptors. All purinergic receptors are divided into P1-purinoreceptors and P2-purinoreceptors. Each of the subtypes is divided into a number of families. For instance, P2 receptors are divided into P2X and P2Y receptors according to the mechanism by which their effect is realized: P2Y are G-protein-coupled receptors, while P2X receptors are ligand-operated ion channels. P2X receptors are important molecular therapeutic targets, the malfunctioning of which leads to severe complications in the physiology of humans and animals and causes dangerous diseases. The search for compounds that can modulate the function of purinergic receptors can lead to the creation of new drugs that are effective in central and peripheral nervous system and immune system disease treatment, including neuroinflammation, hypoxia/ischemia, epilepsy and neuropathic pain. In this Special Issue, we wish to offer a platform for high-quality publications on the latest advances in the identification of P2X/Y- and P1-receptor blockers, functions and regulation by them; the characterization of these receptor signaling networks and crosstalk; mechanisms underlying the role of purinoceptors in neurodegenerative illnesses as well as chronic neuronal changes following acute noxious damage and therapeutic opportunities associated with regulation of purinergic receptor activity.
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Denis Noble sets out an alternative systems biology view: that the genome is not life itself. To understand life, it must be viewed at a variety of different levels, interacting with each other in a complex web. It is that emergent web, from the gene to the wider environment, that is life.
Life (Biology) --- Biology --- Life (Biology).
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Humans have eaten nuts for thousands of years, yet their consumption was discouraged just a few decades ago due to their high-fat content. This perspective began to change in the early 1990s due to seminal publications from the Adventist Health Study, which showed that nut consumption significantly improved heart health-related outcomes. Many randomized clinical trials, epidemiological studies, and in vitro/in vivo mechanistic studies have since explored the role of eating nuts and its relation to health. Similarly, dried fruits have been scrutinized due to their concentrated sugar content despite their non-sodium micronutrient and fiber density. Due to accumulating evidence on nut and dried fruit intake and health outcomes, an international scientific meeting was organized for leading experts to examine and recapitulate in detail what is well known and established and what avenues of knowledge are still lacking in nut and dried fruit research. This book summarizes proceedings from this international scientific meeting and the latest information relating to: (1) energy balance and body weight; (2) insulin resistance and diabetes; (3) lipoproteins and dyslipidemia; (4) gastrointestinal system; (5) inflammation and oxidation; (6) cardiovascular disease; (7) cognition; (8) cancer; (9) dried fruit and health; (10) future lines of research. These findings highlight the beneficial health potentials of nuts for researchers, health professionals, other stakeholders, and the public while simultaneously pinpointing areas for further investigation to continue informing and guiding health practices and policies.
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Annotation The philosophy of Gilbert Simondon has reinvigorated contemporary thinking about biological and technological beings. In this book, Jean-Hugues Barthelemy takes up Simondon's thought and shows how life and technology are connected by a transversal theme: individuation. In the first essay, Barthelemy delivers a contemporary interpretation of Simondon's concept of ontogenesis against the backdrop of biology and cybernetics. In the second essay, he extends his reflections to propose a non-anthropological understanding of technology, and so sets up a confrontation with the work of Martin Heidegger."
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The philosophy of Gilbert Simondon has reinvigorated contemporary thinking about biological and technological beings. In this book, Jean-Hugues Barthélémy takes up Simondon's thought and shows how life and technology are connected by a transversal theme: individuation. In the first essay, Barthélémy delivers a contemporary interpretation of Simondon's concept of ontogenesis against the backdrop of biology and cybernetics. In the second essay, he extends his reflections to propose a non-anthropological understanding of technology, and so sets up a confrontation with the work of Martin Heidegger.
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Abortion, euthanasia, capital punishment, war, genetic engineering and fetal experimentation, environmental and animal rights--these topics inspire some of today's most heated public controversies. And it is fashionable to pursue these debates in terms of the negative query "Under what conditions may life be disregarded or terminated?" John Kleinig asks a different, more positive question: What may be said in behalf of life? Looking at the full range of appeals to life's value, he considers a variety of issues. Is livingness as such to be affirmed and respected? Is there an ascending order of plant, animal, and human life? Does human life possess a distinctive claim, or must we discriminate between humans that do and humans that do not have claims on us? Kleinig shows that assertions about valuing life camouflage a complex normative vocabulary about worth, reverence, sanctity, dignity, respect, and rights. And "life," too, is subject to an assortment of understandings. Sensitive to the frameworks informing diverse appeals to life's value, this comprehensive work will interest readers concerned with the environment, animal rights, or bioethics.Originally published in 1991.The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.
Life. --- Life (Biology) --- Life (Biology). --- Biology --- Life --- Philosophy
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The forum is for scientists doing research in different fields of cell science including, but not limited to, stem cells, autophagy, aging, intracellular organelles, proteomics, genomics, metabolism, and cell physiology. The goal of the symposium was to bring scientists together to facilitate the exchange of data and novel ideas to advance cell science as well as discussing the challenges facing cell biologists.
Cells. --- Life sciences. --- Life (Biology)
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